Arul Chinnaiyan

Arul Chinnaiyan
Alma materUniversity of Michigan Medical School
Known forCancer Research
Scientific career
InstitutionsUniversity of Michigan Medical School, Howard Hughes Medical Institute

Arul M. Chinnaiyan is the S.P. Hicks Endowed Professor of Pathology, a Professor of Urology, and the Director of the Michigan Center for Translational Pathology at the University of Michigan Medical School.[1] He is also a Howard Hughes Medical Institute Investigator and an American Cancer Society Research Professor.[2]

Arul Chinnaiyan received both PhD and MD degrees at the University of Michigan Medical School in 1999. He is a cancer researcher and the recipient of the 28th annual American Association for Cancer Research Award for Outstanding Achievement in Cancer Research at the annual meeting of the AACR in April 2008 in San Diego.[3] He was also the leader of a group of scientists who received the inaugural 2007 American Association for Cancer Research "Team Science" Award for their discovery of gene fusions in prostate cancer.[4]

Arul Chinnaiyan received a number of other awards and prizes, including the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research and of the Ramzi Cotran Young Investigator Award from the United States and Canadian Academy of Pathology. He is an elected member of the American Society for Clinical Investigation[5] and the National Academy of Sciences.[6] He received the 2022 Sjöberg Prize[7] and was jointly awarded the Harrington Prize for Innovation in Medicine[8] alongside Charles L. Sawyers.

He is a member of the editorial board for Oncogene.[9]

Research and discovery

The focus of his research is molecular profiling of cancer to discover novel diagnostic markers and therapeutic targets. It is generally believed that blood cancers are caused by chromosome translocation such as Bcr-Abl in chronic myelogenous leukaemia (CML), whereas solid tumors are caused by mutations in growth or tumour suppressor genes. In research which challenges the current dogma, Arul has discovered chromosome translocation in solid prostate tumours. Arul has discovered that this translocation occurs between a male hormone related gene TMPRSS2 and transcription factors of the Erythroblast transformation specific (ETS) family.[10]

Publications

Partial list:

References

  1. ^ Arul M. Chinnaiyan – University of Michigan Medical School Archived 13 October 2025 at the Wayback Machine
  2. ^ Arul M. Chinnaiyan – HHMI Archived 19 August 2024 at the Wayback Machine
  3. ^ List of AACR Award for Outstanding Achievement in Cancer Research Winners Archived 5 May 2008 at the Wayback Machine
  4. ^ AACR Team Science Award Recipients Archived 10 March 2014 at the Wayback Machine, American Association for Cancer Research Award citation:"In recognition of their landmark discovery of recurrent gene fusions in a majority of prostate cancers, which has profound clinical and biological implications for understanding prostate cancers, and their embodiment of team science through interdisciplinary and inter-institutional collaboration."
  5. ^ 2 UMHS researchers selected as Howard Hughes Medical Institute investigators. Archived 21 April 2008 at the Wayback Machine University of Michigan Health System Press Release. 12 October 2007
  6. ^ Arul M. Chinnaiyan – National Academy of Sciences. Archived 7 December 2025 at the Wayback Machine National Academy of Sciences
  7. ^ Discovery about a cause of prostate cancer rewarded with the Sjöberg Prize. Archived 15 November 2025 at the Wayback Machine Royal Swedish Academy of Sciences. 14 February 2022
  8. ^ International Harrington Prize Jointly Awarded to Drs. Arul Chinnaiyan and Charles Sawyers. Archived 10 April 2026 at the Wayback Machine Harrington Discovery Institute. 24 March 2026
  9. ^ "Editorial Board | Oncogene".
  10. ^ Tomlins, SA; Laxman, B; Dhanasekaran, SM; Helgeson, BE; Cao, X; Morris, DS; Menon, A; Jing, X; Cao, Q; Han, B; Yu, J; Wang, L; Montie, JE; Rubin, MA; Pienta, KJ; Roulston, D; Shah, RB; Varambally, S; Mehra, R; Chinnaiyan, AM (2007). "Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer". Nature. 448 (7153): 595–9. Bibcode:2007Natur.448..595T. doi:10.1038/nature06024. hdl:2027.42/62659. PMID 17671502. S2CID 4361134.

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