ARPC3

ARPC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARPC3, ARC21, p21-Arc, actin related protein 2/3 complex subunit 3
External IDsOMIM: 604225; MGI: 1928375; HomoloGene: 4178; GeneCards: ARPC3; OMA:ARPC3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10094

56378

Ensembl

ENSG00000111229

ENSMUSG00000029465

UniProt

O15145

Q9JM76

RefSeq (mRNA)

NM_001287222
NM_001278556

NM_019824

RefSeq (protein)

NP_001265485
NP_001274151

NP_062798

Location (UCSC)Chr 12: 110.43 – 110.45 MbChr 5: 122.53 – 122.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ARP2/3 complex ARPC3 (21 kDa) subunit
crystal structure of arp2/3 complex with bound adp and calcium
Identifiers
SymbolP21-Arc
PfamPF04062
InterProIPR007204
Available protein structures:
PDB  IPR007204 PF04062 (ECOD; PDBsum)  
AlphaFold

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.[5][6][7]

This gene encodes one of seven subunits of the Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111229 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029465 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  6. ^ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (Jan 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem J. 328 (1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
  7. ^ a b "Entrez Gene: ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa".

Further reading


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