ARPC1A

ARPC1A
Identifiers
AliasesARPC1A, Arc40, HEL-68, SOP2Hs, SOP2L, HEL-S-307, actin related protein 2/3 complex subunit 1A
External IDsOMIM: 604220; MGI: 1928896; HomoloGene: 4675; GeneCards: ARPC1A; OMA:ARPC1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10552

56443

Ensembl

ENSG00000241685

ENSMUSG00000029621

UniProt

Q92747

Q9R0Q6

RefSeq (mRNA)

NM_006409
NM_001190996

NM_019767

RefSeq (protein)

NP_001177925
NP_006400

NP_062741

Location (UCSC)Chr 7: 99.33 – 99.37 MbChr 5: 145.02 – 145.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.[5][6][7]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029621 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Balasubramanian MK, Feoktistova A, McCollum D, Gould KL (Jan 1997). "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function". EMBO J. 15 (23): 6426–37. doi:10.1002/j.1460-2075.1996.tb01034.x. PMC 452468. PMID 8978670.
  6. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  7. ^ a b "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa".

Further reading


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