A1APU

A1APU
Identifiers
  • (2S)-3-(3-methoxy-4-methylphenyl)-N-methyl-2-[[2-[1-(5-phenylmethoxypyridin-3-yl)naphthalen-2-yl]sulfanylacetyl]amino]propanamide
PubChem CID
ChemSpider
Chemical and physical data
FormulaC36H35N3O4S
Molar mass605.75 g·mol−1
3D model (JSmol)
  • CC1=C(C=C(C=C1)C[C@@H](C(=O)NC)NC(=O)CSC2=C(C3=CC=CC=C3C=C2)C4=CC(=CN=C4)OCC5=CC=CC=C5)OC
  • InChI=1S/C36H35N3O4S/c1-24-13-14-26(18-32(24)42-3)17-31(36(41)37-2)39-34(40)23-44-33-16-15-27-11-7-8-12-30(27)35(33)28-19-29(21-38-20-28)43-22-25-9-5-4-6-10-25/h4-16,18-21,31H,17,22-23H2,1-3H3,(H,37,41)(H,39,40)/t31-/m0/s1
  • Key:IBQRWMDLUKSOJL-HKBQPEDESA-N

A1APU (10105-368-30-605-0) is a negative allosteric modulator (NAM) of the μ-opioid receptor (MOR) which has been developed as a potential treatment for opioid overdose. In animal studies it increases the potency and effective duration of naloxone making it able to block opioid-induced respiratory depression at a tenth of the normal dose.[1][2]

See also

References

  1. ^ O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, et al. (July 2024). "A µ-opioid receptor modulator that works cooperatively with naloxone". Nature. 631 (8021): 686–693. Bibcode:2024Natur.631..686O. doi:10.1038/s41586-024-07587-7. PMC 11998091. PMID 38961287.
  2. ^ WO 2024/112721, O'Brian E, Kumar KK, Kobilka B, "Allosteric Modulators of the μ-Opioid Receptor and Cannabinoid receptor 1", published 2024-05-30, assigned to Cz Biohub Sf, Llc and The Board Of Trustees Of The Leland Stanford Junior University 

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.