Lin-12

Lin-12 ist ein Gen des Wurmes Caenorhabditis elegans, das zusammen mit dem Glucagon-like Peptid 1 (glp-1) Gen für die Proteine Notch/Lin-12 kodiert. Das Gen wurde entdeckt, als man nach Genen suchte, deren Mutationen für eine defekte Vulva des Wurmes (der Wurm ist ein Zwitter) verantwortlich sind. Lin-12 ist wichtig für die Entwicklung der Geschlechtsorgane des Wurmes.

In der Alzheimer-Forschung ist Lin-12 interessant, da der Proteinkomplex Gamma-Sekretase, der Notch/LIN-12 proteolytisch schneidet, ebenfalls den Schnitt des Amyloid-Precursor-Proteins vermittelt.

Literatur

  • I. Greenwald: LIN-12/Notch signaling: lessons from worms and flies. In: Genes Dev. 1998 Jun 15;12(12), S. 1751–1762. PMID 9637676 (free full text)
  • D. D. Shaye, I. Greenwald: LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. In: Development. 2005 Nov;132(22), S. 5081–5092. Epub 2005 Oct 19. PMID 16236769 (free full text)

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