ICAM-3

Intercellular adhesion molecule 3
Intercellular adhesion molecule 3
nach PDB 1T0P
Andere Namen

CDw50, ICAM-R, CD_antigen: CD50

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 547 Aminosäuren, 59.541 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe (Mensch)
Entrez 3385
Ensembl ENSG00000076662
UniProt P32942
Refseq (mRNA) NM_001320605.1
Refseq (Protein) NP_001307534.1
PubMed-Suche 3385

Das Interzelluläre Adhäsionsmolekül 3 (engl. Intercellular adhesion molecule 3; ICAM-3, CD50) ist ein Oberflächenprotein aus der Gruppe der Zelladhäsionsmoleküle.

Eigenschaften

ICAM-3 wird von Leukozyten gebildet. Es bindet an LFA-1 (Komplex aus Integrin alpha-L und Integrin beta-2) und an den Komplex aus Integrin alpha-D und Integrin beta-2. Die Bindung von ICAM-3 an Integrin alpha-D und Integrin beta-2 ist an der Phagozytose von apoptotischen Neutrophilen durch Makrophagen beteiligt.[1] ICAM-3 ist glykosyliert und phosphoryliert.

Einzelnachweise

  1. ↑ E. Kristóf, G. Zahuczky, K. Katona, Z. Doró, É. Nagy, L. Fésüs Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. In: Apoptosis. Band 18, Nummer 10, Oktober 2013, S. 1235–1251, doi:10.1007/s10495-013-0873-z, PMID 23775590.

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