CD6

T-cell differentiation antigen CD6
Andere Namen

T12, TP120

Vorhandene Strukturdaten: PDB 5A2E

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 668 Aminosäuren, 71.801 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen

T-cell differentiation antigen CD6 ist ein Oberflächenprotein aus der Gruppe der Zelladhäsionsmoleküle.

Eigenschaften

CD6 wird von Thymozyten, NK-Zellen und B1-Zellen gebildet. Es ist ein Zelladhäsionsmolekül, das die T-Zell-Antwort verstärkt.[1] CD6 bindet an Lipopolysaccharid von Gram-negativen Bakterien und Lipoteichonsäuren von Gram-positiven Bakterien und aktiviert daraufhin den MAPK-Signalweg.[2] CD6 ist glykosyliert, phosphoryliert und besitzt Disulfidbrücken.

Einzelnachweise

  1. ↑ I. Gimferrer, M. Calvo, M. Mittelbrunn, M. Farnós, M. R. Sarrias, C. Enrich, J. Vives, F. Sánchez-Madrid, F. Lozano: Relevance of CD6-mediated interactions in T cell activation and proliferation. In: Journal of Immunology. Band 173, Nummer 4, August 2004, S. 2262–2270, PMID 15294938.
  2. ↑ M. R. Sarrias, M. Farnós, R. Mota, F. Sánchez-Barbero, A. Ibáñez, I. Gimferrer, J. Vera, R. Fenutría, C. Casals, J. Yélamos, F. Lozano: CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. In: Proceedings of the National Academy of Sciences. Band 104, Nummer 28, Juli 2007, S. 11724–11729, doi:10.1073/pnas.0702815104, PMID 17601777, PMC 1913855 (freier Volltext).

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