CD49f
| Integrin alpha-6 | ||
|---|---|---|
| Andere Namen |
CD49 antigen-like family member F, VLA-6, CD_antigen: CD49f | |
| Eigenschaften des menschlichen Proteins | ||
| Masse/Länge Primärstruktur | 1.130 Aminosäuren, 126.606 Da | |
| Bezeichner | ||
| Externe IDs | ||
| Vorkommen | ||
| Homologie-Familie | Hovergen | |
| Orthologe (Mensch) | ||
| Entrez | 3655 | |
| Ensembl | ENSG00000091409 | |
| UniProt | P23229 | |
| Refseq (mRNA) | NM_000210.3 | |
| Refseq (Protein) | NP_000201.2 | |
| PubMed-Suche | 3655
| |
Integrin α-6 (synonym CD49f) ist ein Oberflächenprotein aus der Gruppe der Integrine.
Eigenschaften
Integrin α-6 ist ein Zelladhäsionsmolekül. Es bildet mit Integrin beta-1 und Integrin beta-4 einen heterodimeren Rezeptor für Laminin auf Thrombozyten bzw. Laminin auf Epithelzellen, IGF1 und NRG1. Integrin α-6 ist glykosyliert, phosphoryliert und palmitoyliert. Es ist ein Zelltypmarker für Stammzellen der männlichen Keimbahn.[1] Mutationen des Integrins α-6 sind an der Entstehung von Epidermolysis bullosa beteiligt.
Integrin α-6 bindet an TSPAN4[2] und GIPC1.[3]
Weblinks
Einzelnachweise
- ↑ R. Sá, C. Miranda, F. Carvalho, A. Barros, M. Sousa: Expression of stem cell markers: OCT4, KIT, ITGA6, and ITGB1 in the male germinal epithelium. In: Systems biology in reproductive medicine. Band 59, Nummer 5, Oktober 2013, S. 233–243, doi:10.3109/19396368.2013.804964, PMID 23758503.
- ↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME: NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. In: The Journal of Biological Chemistry. 272. Jahrgang, Nr. 46, November 1997, S. 29181–9, doi:10.1074/jbc.272.46.29181, PMID 9360996 (englisch).
- ↑ Tani TT, Mercurio AM: PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. In: The Journal of Biological Chemistry. 276. Jahrgang, Nr. 39, September 2001, S. 36535–42, doi:10.1074/jbc.M105785200, PMID 11479315 (englisch).
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