CCL22

CCL22
Andere Namen
  • Chemokine (C-C Motif) Ligand 22
  • SCYA22
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22
  • Stimulated T-Cell Chemotactic Protein 1
  • Macrophage-Derived Chemokine
  • CC Chemokine STCP-1
  • MDC(1-69)
  • A-152E5.1
  • DC/B-CK
  • ABCD-1
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 93 Aminosäuren, 10625 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe
Mensch Hausmaus
Entrez 6367 20299
UniProt O00626 O88430
PubMed-Suche 6367 20299

CCL22 (englisch CC-chemokine ligand 22) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL22 ist an Entzündungsprozessen beteiligt. Es bindet an CCR4.[1] CCL22 wird von Makrophagen und dendritischen Zellen gebildet und bindet dendritische Zellen und TH2-Zellen.[2] Es wird durch die Zytokine Interleukin-4 und Interleukin-5 induziert und durch Interferon-gamma herabreguliert.[2] CCL22 ist an einer TH2-Hypersensitivität der Atemwege und an der atopischen Dermatitis beteiligt.[2]

Einzelnachweise

  1. ↑ M. Vulcano, C. Albanesi, A. Stoppacciaro, R. Bagnati, G. D’Amico, S. Struyf, P. Transidico, R. Bonecchi, A. Del Prete, P. Allavena, L. P. Ruco, C. Chiabrando, G. Girolomoni, A. Mantovani, S. Sozzani: Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. In: European Journal of Immunology. Band 31, Nummer 3, März 2001, S. 812–822, doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L, PMID 11241286.
  2. ↑ a b c U. Yamashita, E. Kuroda: Regulation of macrophage-derived chemokine (MDC, CCL22) production. In: Critical reviews in immunology. Band 22, Nummer 2, 2002, S. 105–114, PMID 12433129.

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