Tetramer

Podjedinice ljudskog hemoglobina: proteinske α i β podjedinice obojene su crveno i plavo.

Tetramer (grč. τετρα - tetra = četiri + µέρος meros = dio) je oligomer nastao od četiri monomera ili podjedinice. Osobina povezivanje naziva se tetramerija. Primjer iz anorganske hemije je titan-metoksid sa empirijskom formulom Ti(OCH3)4, koji je u čvrstom stanju tetrameran i ima molekulsku formulu Ti4(OCH3)16.[1] Primjer iz organske hemije je kobofenol A, supstanca koja nastaje kombiniranjem četiri molekula resveratrola.[2][3]

U biohemiji se slično odnosi na biomolekulu formiranu od četiri jedinice koje su jednake (homotetramer, tj. kao u konkanavalinu A ili različite (heterotetramer), tj. kao hemoglobinu. Hemoglobin ima četiri slične podjedinice, dok imunoglobulin imaju dvije vrlo različite podjedinice. Svaka od podjedinica može imati svoju aktivnost, poput vezanja biotina u avidinskim tetramerima, ili imaju zajedničko biološko svojstvo, kao što je alosterno vezanje kisika u hemoglobinu.

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Reference

  1. ^ Wright, D. A.; Williams, D. A. (1968). "The crystal and molecular structure of titanium tetramethoxide". Acta Crystallogr. B. 24 (8): 1107–1114. doi:10.1107/S0567740868003766.
  2. ^ Shu, Na; Zhou, Hong; Hu, Changqi (2006). "Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method". Biol. Pharm. Bull. 29 (4): 608–612. doi:10.1248/bpb.29.608. PMID 16595888.
  3. ^ Li, Liya; Henry, Geneive E.; Seeram, Navindra P. (2009). "Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds". J. Agric. Food Chem. 57 (16): 7282–7287. doi:10.1021/jf901716j.

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