Termosom

Termosomski hetero16-mer kod Sulfolobus solfataricus

Termosom je grupa II šaperonina kompleksni protein koji funkcionira u arhejama. To je homolog eukariotskog CCT. Ovaj šaperonin grupe II je ATP-zavisni šaperonin koji je odgovoran za presavijanje uopće ili presavijanje početnog sastojka ili denaturiranih proteina.[1] Termosom ima dva prstena, od kojih se svaki sastoji od po osam podjedinice, složenih zajedno tako da formiraju cilindrični oblik s velikom šupljinom u središtu.[1] Teakođer je definiran heterooligomernom prirodom.

Budući da je šaperonin grupe II, termosom ima sličnu strukturu kao šaperonini grupe I. Glavna razlika, međutim, je u postojanju spiralne izbočine u termosomu koja se sastoji od ugrađenog poklopca hidrofilne šupljine.[1] Ne samo da je termosom ATP-zavisan, nego mehanizam u kojem se termosom prebacuje iz otvorene u zatvorenu konformaciju također zavisi od temperature. Otvorena konformacija ATP-termosoma postoji uglavnom na niskim temperaturama.[2] Dok se zatvorena konformacija termosoma javlja prilikom zagrijavanja na fiziološku.[2]

Reference

  1. ^ a b c Klumpp, M.; Baumeister, W. (23. 6. 1998). "The thermosome: archetype of group II chaperonins". FEBS Letters. 430 (1–2): 73–77. doi:10.1016/s0014-5793(98)00541-9. ISSN 0014-5793. PMID 9678597.
  2. ^ a b Gutsche, I.; Holzinger, J.; Rauh, N.; Baumeister, W.; May, R. P. (august 2001). "ATP-induced structural change of the thermosome is temperature-dependent". Journal of Structural Biology. 135 (2): 139–146. doi:10.1006/jsbi.2001.4373. ISSN 1047-8477. PMID 11580263.

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