PVT1

PVT1
Identifikatori
AliasiPVT1
Vanjski ID-jeviOMIM: 165140 GeneCards: PVT1
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za PVT1
Genomska lokacija za PVT1
Bend8q24.21Početak127,794,526 bp[1]
Kraj128,187,101 bp[1]
Ortolozi
VrsteČovjekMiš
Entrez

5820

n/a

Ensembl

ENSG00000249859

n/a

UniProt

n
a

n/a

RefSeq (mRNK)

n/a

n/a

RefSeq (bjelančevina)

n/a

n/a

Lokacija (UCSC)Chr 8: 127.79 – 128.19 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

Nekodirajući onkogen Pvt1, znan i kao PVT1 ili plazmacitomna varijanta translokacije 1 je gen dugolančane nekodirajuće RNK.[3]

Funkcija

Kod miševa, ovaj gen je identificiran kao mjesto loma u hromosomu 6; translokacije u hromosomu 15. Ove translokacije su povezane sa mišjim plazmacitomima.[4] Ekvivalentna translokacija kod ljudi je t (2;8) na htomosomu 8, koja je povezana s rijetkom varijantom Burkittovog limfoma.[5] Kod pacova, pokazalo se da je ova tačka prekida uobičajeno mjesto provirusna integracijska u retrovirusnim induciranim T-limfomima.[6] Transkripciju PVT1 regulira Myc.[7]

Prekomjerna ekspresija PVT1 može dovesti do tumorigeneze na tri načina. Preuređivanje fuzijomDNK PVT1 i onkogenskog tumorskog supresora moglo bi dovesti do disregulacije onkogena ili supresije tumora, što je na kraju dovodi do tumorigeneze. Zatim, ekspresija miRNK kodiranih putem PVT1 može smanjiti regulaciju gena za suzbijanje tumora, uzrokujući tumorigenezu. Konačno, povećanje interakcije MYC s PVT1 može takođđer dovesti do tumorigeneze.[8]

Nadekspresija PVT1 koji se nalazi u regiji 8q24.21 povezana je s mnogim tipovima raka kod ljudi [8] disregulacijom određenih različitih gena u različitim tipovima raka. Naprimjer, prekomjerna ekspresija PVT1 u raku prostate snižava ekspresiju gena miR-146a, što dovodi do smanjenja nivoa miR-146a u ćeliji, putem metilacija CpG-otoka na promotorskoj regiji, podstičući suzbijanje ćelija raka apoptozom.[9] Nadalje, pokazalo se da aktivnost lncPVT1 i s njim povezanih mikroRNK utiče na otpornost na hemoterapiju u više tipova raka epigenetičkom regulacijom ili direktnom represijom drugih nekodiranih transkripata.[10]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000249859 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: PVT1 Pvt1 oncogene homolog, MYC activator (mouse)".
  4. ^ Cory S, Graham M, Webb E, Corcoran L, Adams JM (mart 1985). "Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene". The EMBO Journal. 4 (3): 675–681. doi:10.1002/j.1460-2075.1985.tb03682.x. PMC 554241. PMID 3924592.
  5. ^ Graham M, Adams JM (novembar 1986). "Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus". The EMBO Journal. 5 (11): 2845–2851. doi:10.1002/j.1460-2075.1986.tb04578.x. PMC 1167233. PMID 3024964.
  6. ^ Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams JM (maj 1986). "Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas". Molecular and Cellular Biology. 6 (5): 1834–1837. doi:10.1128/MCB.6.5.1834. PMC 367714. PMID 3785181.
  7. ^ Carramusa L, Contino F, Ferro A, Minafra L, Perconti G, Giallongo A, Feo S (novembar 2007). "The PVT-1 oncogene is a MYC protein target that is overexpressed in transformed cells". Journal of Cellular Physiology. 213 (2): 511–518. doi:10.1002/jcp.21133. PMID 17503467.
  8. ^ a b Cui M, You L, Ren X, Zhao W, Liao Q, Zhao Y (februar 2016). "Long non-coding RNA PVT1 and cancer". Biochemical and Biophysical Research Communications. 471 (1): 10–14. doi:10.1016/j.bbrc.2015.12.101. PMID 26850852.
  9. ^ Liu HT, Fang L, Cheng YX, Sun Q (decembar 2016). "LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR-146a". Cancer Medicine. 5 (12): 3512–3519. doi:10.1002/cam4.900. PMC 5224852. PMID 27794184.
  10. ^ Ogunwobi OO, Kumar A (august 2019). "Chemoresistance Mediated by ceRNA Networks Associated With the PVT1 Locus". Frontiers in Oncology. 9 (1): 834. doi:10.3389/fonc.2019.00834. PMC 6718704. PMID 31508377.

Dopunska literatura

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