DSE
O Epimerase de sulfato de dermatano é uma enzima que em humanos é codificada pelo gene DSE.[2][3][4][5][6] A proteína codificada por este gene é um antígeno de rejeição de tumor. Este antígeno possui epitopos tumorais capazes de induzir linfócitos T citotóxicos restritos a HLA-A24 e citotóxicos específicos para tumores em pacientes com câncer e podem ser úteis para imunoterapia específica. Este produto gênico está localizado no retículo endoplasmático. Duas variantes transcritas que codificam a mesma proteína foram encontradas para este gene.[4]
Referências
- ↑ «Human PubMed Reference:»
- ↑ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (março de 2002). «Expression of tumor rejection antigens in colorectal carcinomas». Cancer. 94 (6): 1636–41. PMID 11920522. doi:10.1002/cncr.10421
- ↑ Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (abril de 2006). «Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2». J Biol Chem. 281 (17): 11560–8. PMID 16505484. doi:10.1074/jbc.M513373200
- ↑ a b «Entrez Gene: DSE dermatan sulfate epimerase»
- ↑ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (março de 2002). «Expression of tumor rejection antigens in colorectal carcinomas». Cancer. 94 (6): 1636–41. PMID 11920522. doi:10.1002/cncr.10421
- ↑ Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (abril de 2006). «Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2». J. Biol. Chem. 281 (17): 11560–8. PMID 16505484. doi:10.1074/jbc.M513373200
Leitura adicional
- Nakao M, Shichijo S, Imaizumi T, et al. (2000). «Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL». J. Immunol. 164 (5): 2565–74. PMID 10679095. doi:10.4049/jimmunol.164.5.2565
- Tanaka S, Tsuda N, Kawano K, et al. (2001). «Expression of tumor-rejection antigens in gynecologic cancers». Jpn. J. Cancer Res. 91 (11): 1177–84. PMC 5926290
. PMID 11092984. doi:10.1111/j.1349-7006.2000.tb00902.x - Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). «Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes». Genome Res. 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.