CLEC5A
| CLEC5A | |||||
|---|---|---|---|---|---|
| Indicadores | |||||
| Símbolo | CLEC5A | ||||
| Símbolos alt. | CLECSF5, MDL-1, MDL1 | ||||
| Entrez | 23601 | ||||
| RefSeq | NP_001288096 | ||||
| UniProt | Q9NY25 | ||||
| Outros dados | |||||
| Locus | Cr. 7 7q34(141.93 – 141.95 Mb) | ||||
| |||||
O CLEC5A (do inglês C-type lectin domain family 5 member A, ou membro A da família do domínio da lectina tipo C 5), também chamado CLECFSF5 (do inglês C-type lectin superfamily member 5, ou membro 5 da super-família de lectina tipo C) e MDL1 (do inglês myeloid DAP12-associating lectin 1, ou lectina 1 associada a DAP12 mieloide) é uma lectina tipo C que nos humanos está codificada pelo gene CLEC5A, localizado no cromossoma 7.[1][2] Parece ser um membro duma importante via de activação da linhagem mielóide. É uma proteína necessária para o desenvolvimento da doença do dengue.[3]
Referências
- ↑ «Entrez Gene: C-type lectin domain family 5»
- ↑ Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (Agosto de 1999). «Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells». Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. PMC 22289
. PMID 10449773. doi:10.1073/pnas.96.17.9792
- ↑ Chen ST, Lin YL, Huang MT, et al. (2008). «CLEC5A is critical for dengue-virus-induced lethal disease.». Nature. 453 (7195): 672–6. PMID 18496526. doi:10.1038/nature07013
Ligações externas
- UCSC gene info CLEC5A
Bibliografia
- Joyce-Shaikh B; et al. (2010). «Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.». J Exp Med. 207 (3): 579–89. PMC 2839155. PMID 20212065. doi:10.1084/jem.20090516
- Davila S, Froeling FE, Tan A, et al. (2010). «New genetic associations detected in a host response study to hepatitis B vaccine.». Genes Immun. 11 (3): 232–8. PMID 20237496. doi:10.1038/gene.2010.1
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). «Human chromosome 7: DNA sequence and biology.». Science. 300 (5620): 767–72. PMC 2882961. PMID 12690205. doi:10.1126/science.1083423
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). «The DNA sequence of human chromosome 7.». Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782
- Ebner S, Sharon N, Ben-Tal N (2003). «Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.». Proteins. 53 (1): 44–55. PMID 12945048. doi:10.1002/prot.10440
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Drickamer K (1999). «C-type lectin-like domains.». Curr. Opin. Struct. Biol. 9 (5): 585–90. PMID 10508765. doi:10.1016/S0959-440X(99)00009-3
- Watson AA, O'Callaghan CA (2010). «Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.». Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 1): 29–31. PMC 2805530. PMID 20057064. doi:10.1107/S1744309109047915
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