In the not-too-distant future, the most cutting-edge technology has honed romantic relationships down to a science: A computerized test can determine the likelihood of successful partnership between two individuals, and androids—known as “synthetics”—have been designed as the ideal partners, ones who are completely understanding and will never leave. Zoe and Cole work in the research facility responsible for developing this technology. Zoe and Cole are friends but Zoe harbors a crush on him, and is disappointed when she takes the compatibility test and finds out they have a 0% compatibility. When she tells Cole this information, he gently tells her that she is a synthetic.
Synthetics had always been programmed to know they were synthetics, but Zoe was a new model and an experiment to see if a synthetic could pass as a human. Although Zoe has been implanted with false memories that she believed were her own, as in Blade Runner, it is clear that Zoe is special as she has developed her own feelings. Cole gently takes Zoe into the world with this new self-awareness, seeing her reactions, but also falling in love with her. He is wary of getting physical with her, but they eventually do. Zoe feels that Cole is holding back.
When Zoe is hit by a car, exposing her synthetic intestines, it causes Cole to pull away from Zoe after repairing her. Meanwhile, the AI company has shifted direction to releasing Benysol, a pill which gives the person taking it the feeling of being in love for several blissful hours. It is a huge success, with people going to Benysol clubs and even hanging out in certain parks to meet partners they take it with. Cole and Zoe clearly miss each other, but they both take Benysol with multiple partners, which only leaves them feeling empty. Cole's friends encourage him to be with Zoe, even though she is synthetic, but he cannot do it. One day Zoe visits the AI lab and discovers a room full of Zoes, the next generation of her, Zoe 2.0. She realizes she that does not wish to live without Cole and visits the brothel where she asks the owner to shut her down. However, at the last minute she changes her mind and some of the brothel girls take her to her apartment, where Cole finds her and professes his love. She cries, which her model was not supposed to be able to do.
On review aggregator website Rotten Tomatoes, the film holds an approval rating of 32%, based on 25 reviews, and an average rating of 4.3/10. Its consensus states "Zoe has some interesting ideas but never manages to get a satisfying grip on them, settling for slow-moving sci-fi that ultimately fails to engage."[13] On Metacritic, the film has a weighted average score of 39 out of 100, based on 10 critics, indicating "generally unfavorable reviews".[14] Morgan Rojas of Cinemacy believed that "the performances from McGregor and Seydoux are equally raw and vulnerable", and that Aguilera added a "star power" to the film.[15]Common Sense Media editor Andrea Beach praised the movie for the two leading performances and additional work by "talented supporters—Rashida Jones, Miranda Otto, and Christina Aguilera".[16]