After graduation, Sproul acquired an interest in the Franklin Printing Company of Philadelphia. Sproul later purchased a half interest in the Chester Times newspaper.[4]
Sproul was employed in the field of newspaper publishing, and rose to the rank of president of the Chester Daily Times.[5] Additionally, he made a substantial profit through investments in railroads and manufacturing interests.
In 1895, Sproul was elected a director of the First National Bank of Chester.
Willim Cameron Sproul and son Jack in Armistice Day parade, November 11, 1918
A prominent Republican, Sproul served in the Pennsylvania State Senate for the 9th District from 1897 to 1919. At age 26, he was the youngest member of the senate and the youngest man to become senator from Delaware County.[3] In 1911, he drafted the landmark Sproul Road Bill, which created the state highway system.
In 1918, Sproul was elected as the 27th Governor of Pennsylvania and served until 1923. As governor, he focused on expanding funding for education, roadway construction, and veterans' services. He also spurred an effort to expand state forest land in order to replenish the state's woodlands after years of depletion by lumber companies.
Sproul was a candidate for the Republican presidential nomination in 1920. He was later offered the nomination for vice president on a ticket with Warren Harding, but he declined. In 1926, Sproul chaired the bi-state committee that organized the construction of the Benjamin Franklin Bridge between Philadelphia and Camden.
On January 21, 1892, Sproul married Emeline Wallace Roach, the daughter of shipbuilder John Roach.[7] They had two children, Dorothy Wallace Sproul (1892–1931) and John Roach Sproul (1894–1949), who married Henry D. Hatfield's daughter, Hazel Bronson Hatfield.
Although Sproul was a millionaire, he died intestate on March 21, 1928.[2] He is interred at the Chester Rural Cemetery in Chester, Pennsylvania.[7]