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The first paragraph is without citation and quite likely wrong. It states things rather black and white w/o the sort of discussion this requires. To stand, it will need to be pretty well referenced and explain why the underlying mechanism why you cannot tolerate a medication (which you may never know--but you will know you are intolerant of it, because, well you cannot tolerate it) is a defining feature. — Preceding unsigned comment added by 75.73.1.89 (talk) 08:15, 17 July 2014 (UTC)[reply]

I agree that the leading paragraph has problems. I disagree with the claim that "Drug intolerance or drug sensitivity is a lower threshold to the normal pharmacologic action of a drug;" it's not about a threshold to "normal pharmacologic action," but rather a lower threshold for toxicity/ADRs. It would probably be worth discussing the concepts of TI, ADRs, and therapeutic effect. Biochemistry&Love (talk) 04:13, 13 April 2017 (UTC)[reply]

I think it would be useful to distinguish drug intolerance from drug sensitivity. Drug intolerance isn't necessarily due to drug sensitivity, which I see as an example of a physiological drug intolerance (which could be genetic in nature or due to clinical circumstances, like a DDI or a disease state that alters the ADME properties of a drug, inducing a complication like metabolic acidosis).

There's also the case of what I might call psychosomatic drug intolerance, which is more of a subjective (and idiopathic?) cause of drug intolerance. Just as different people have different pain tolerances, so too do people have different tolerances for dealing with the adverse effects from their medications. For example, while opioid-induced constipation may be tolerable to some individuals, other people may stop taking an opioid due to the unpleasantness of the constipation even if it brings them significant pain relief.

Any thoughts on this? Biochemistry&Love (talk) 19:05, 25 April 2017 (UTC)[reply]

In the first paragraph, the article states that drug intolerance "is not to be confused with a drug allergy, which is a form of drug intolerance, but requires an immune-mediated component." In this case, the circle labeled "drug allergy" should be completely inside the circle for "drug intolerance" in the venn diagram since drug allergy is a form of drug intolerance. William2001^(talk) 03:30, 11 March 2018 (UTC)[reply]

Agreed! Thank you for pointing that out. I've adjusted the image per your suggestion. ―Biochemistry🙴❤ 23:44, 12 March 2018 (UTC)[reply]