When acute it can cause a medical emergency independent of its cause, and require swift diagnosis and treatment to prevent long-term disability due to irreversible spinal cord injury.
Typically, the symptoms of spinal cord compression develop slowly and progress steadily over several years. In some patients, however, the condition may worsen more rapidly. Subacute compression develops over days to weeks. Acute compression develops within minutes to hours. Acute compression may follow subacute and chronic compression, especially if the cause is abscess or tumor. Regardless of the pace, spinal cord compression will predictably progress over time. [1][2]
Surgery is indicated in localised compression as long as there is some hope of regaining function. It is also occasionally indicated in patients with little hope of regaining function but with uncontrolled pain. Postoperative radiation is delivered within 2–3 weeks of surgical decompression. Emergency radiation therapy (usually 20 grays in 5 fractions, 30 grays in 10 fractions or 8 grays in 1 fraction) is the mainstay of treatment for malignant spinal cord compression. It is very effective as pain control and local disease control. Some tumours are highly sensitive to chemotherapy (e.g. lymphomas, small-cell lung cancer) and may be treated with chemotherapy alone.
Prognosis
Once complete paralysis has been present for more than about 24 hours before treatment, the chances of useful recovery are greatly diminished, although slow recovery, sometimes months after radiotherapy, is well recognised.
The median survival of patients with metastatic spinal cord compression is about 12 weeks, reflecting the generally advanced nature of the underlying malignant disease. [citation needed]
^Anthony S. Fauci; Eugene Braunwald; Dennis L. Kasper; Stephen L. Hauser; Dan L. Longo; J. Larry Jameson; Joseph Loscalzo (19 March 2009). Harrison's Manual of Medicine. McGraw Hill Professional. pp. 94–. ISBN978-0-07-147743-7. Retrieved 17 April 2010.
Loblaw DA, Perry J, Chambers A, Laperriere NJ (March 2005). "Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group". J. Clin. Oncol.23 (9): 2028–37. doi:10.1200/JCO.2005.00.067. PMID15774794.