Sir Thomas Twisden, 1st Baronet (2 January 1602 – 2 January 1683) was an English lawyer and politician who sat in the House of Commons of England in two periods between 1646 and 1660. He was a High Court judge who presided at the trial of the regicides.
Twisden married Jane Tomlinson, daughter of John Tomlinson, of St Michael's-le-Belfry, York, and Eleanor Dodsworth, and sister of the regicide Matthew Tomlinson (whose life was spared at the Restoration), and had eleven children. His son Roger succeeded to the baronetcy and his daughter Margaret married Sir Thomas Style, 2nd Baronet. His brother was the baronet under the original spelling Sir Roger Twysden, 2nd Baronet.[1]