en SLC26A8

SLC26A8
Identifiers
Aliases	SLC26A8, SPGF3, TAT1, solute carrier family 26 member 8
External IDs	OMIM: 608480; MGI: 2385046; HomoloGene: 27095; GeneCards: SLC26A8; OMA:SLC26A8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,024,868 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,909,207 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; secondary oocyte; ; sperm; ; testicle; ; blood; ; bone marrow cells; ; right frontal lobe;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; neural layer of retina; ; superior frontal gyrus; ; primary visual cortex; ; granulocyte; ; embryo; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	anion transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; oxalate transmembrane transporter activity; protein binding; chloride channel activity; chloride transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	flagellated sperm motility; cell differentiation; oxalate transport; sulfate transport; regulation of membrane potential; regulation of intracellular pH; ion transport; anion transport; multicellular organism development; bicarbonate transport; meiosis; transmembrane transport; spermatogenesis; sperm capacitation; chloride transport; chloride transmembrane transport; sulfate transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	116369
	224661
	ENSG00000112053
	ENSMUSG00000036196
	Q96RN1
	Q8R0C3
	NM_001193476; NM_052961; NM_138718
	NM_001290320; NM_146076
	NP_001180405; NP_443193; NP_619732
	NP_001277249
	Wikidata
View/Edit Human	View/Edit Mouse

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.^[5]^[6]^[7]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.^[7]

Interactions

SLC26A8 has been shown to interact with RACGAP1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112053 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036196 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
^ ^a ^b "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
^ Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

SLC26A8

Function

Interactions

References

Further reading