Protein-coding gene in the species Homo sapiens
Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7 .[ 5] [ 6] [ 7]
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions , some of which are potentially toxic . The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney . Alternatively spliced transcript variants encoding different isoforms have been described.[ 7]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [ § 1]
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Fluorouracil (5-FU) Activity
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See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000137204 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067144 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver" . FEBS Lett . 429 (2): 179–82. doi :10.1016/S0014-5793(98)00585-7 PMID 9650585 . S2CID 30015233 . ^ Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet . 88 (1–2): 76–7. doi :10.1159/000015489 . PMID 10773670 . S2CID 8702529 . ^ a b "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7" .
Further reading
Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP" . Mol. Pharmacol . 73 (4): 1151–8. doi :10.1124/mol.107.043117 . PMC 2698938 PMID 18216183 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther . 301 (3): 797–802. doi :10.1124/jpet.301.3.797 . PMID 12023506 . Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther . 301 (1): 293–8. doi :10.1124/jpet.301.1.293 . PMID 11907186 . S2CID 7739298 . Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline" . Jpn. J. Pharmacol . 88 (1): 69–76. doi :10.1254/jjp.88.69 PMID 11855680 . Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun . 283 (2): 417–22. doi :10.1006/bbrc.2001.4774 . PMID 11327718 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):
