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RTN3
Identifiers
Aliases	RTN3, ASYIP, HAP, NSPL2, NSPLII, RTN3-A1, reticulon 3
External IDs	OMIM: 604249; MGI: 1339970; HomoloGene: 24934; GeneCards: RTN3; OMA:RTN3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	63,759,891 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	7,460,646 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; prefrontal cortex; ; right frontal lobe; ; anterior cingulate cortex; ; ganglionic eminence; ; pons; ; ventricular zone; ; hypothalamus; ; C1 segment; ; amygdala;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; central gray substance of midbrain; ; nucleus of stria terminalis; ; primary motor cortex; ; medial vestibular nucleus; ; prefrontal cortex; ; motor neuron; ; dorsomedial hypothalamic nucleus; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum; membrane; endoplasmic reticulum membrane; plasma membrane; extracellular space; synapse;
Biological process	endoplasmic reticulum tubular network organization; viral process; vesicle-mediated transport; apoptotic process; endoplasmic reticulum tubular network formation;
	Sources:Amigo / QuickGO
Orthologs
	10313
	20168
	ENSG00000133318
	ENSMUSG00000024758
	O95197
	Q9ES97
NM_001265589; NM_001265590; NM_001265591; NM_006054; NM_201428;
	NM_201429; NM_201430
NM_001003930; NM_001003933; NM_001003934; NM_001271486; NM_001271487;
	NM_053076
NP_001252518; NP_001252519; NP_001252520; NP_006045; NP_958831;
	NP_958832; NP_958833
	NP_001003933; NP_001003934; NP_001258415; NP_001258416; NP_444306
	Wikidata
View/Edit Human	View/Edit Mouse

Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.^[5]^[6]

The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133318 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024758 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moreira EF, Jaworski CJ, Rodriguez IR (Jul 1999). "Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13". Genomics. 58 (1): 73–81. doi:10.1006/geno.1999.5807. PMID 10331947.
^ ^a ^b "Entrez Gene: RTN3 reticulon 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Qu X, Qi Y, Qi B (2002). "Generation of multiple mRNA transcripts from the novel human apoptosis-inducing gene hap by alternative polyadenylation utilization and the translational activation function of 3' untranslated region". Arch. Biochem. Biophys. 400 (2): 233–44. doi:10.1016/S0003-9861(02)00016-4. PMID 12054434.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Qi B, Qi Y, Watari A, et al. (2003). "Pro-apoptotic ASY/Nogo-B protein associates with ASYIP". J. Cell. Physiol. 196 (2): 312–8. doi:10.1002/jcp.10297. PMID 12811824. S2CID 7066102.
Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family" (PDF). FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288. S2CID 27903.
Di Sano F, Fazi B, Citro G, et al. (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID 12873973.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Huang X, Yang H, Zhou Y, et al. (2004). "Overexpression of human reticulon 3 (hRTN3) in astrocytoma". Clin. Neuropathol. 23 (1): 1–7. PMID 14986927.
Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784. S2CID 23570406.
Di Scala F, Dupuis L, Gaiddon C, et al. (2005). "Tissue specificity and regulation of the N-terminal diversity of reticulon 3". Biochem. J. 385 (Pt 1): 125–34. doi:10.1042/BJ20040458. PMC 1134680. PMID 15350194.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gan M, Qi Y, Wan Q, et al. (2005). "Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death". Mol. Biol. Rep. 31 (3): 159–64. doi:10.1023/B:MOLE.0000043551.84883.c8. PMID 15560370. S2CID 11901566.
Kuang E, Wan Q, Li X, et al. (2005). "ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP)". J. Cell. Physiol. 204 (2): 549–59. doi:10.1002/jcp.20340. PMID 15799019. S2CID 30086875.
Cai Y, Saiyin H, Lin Q, et al. (2005). "Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain". Brain Res. Mol. Brain Res. 138 (2): 236–43. doi:10.1016/j.molbrainres.2005.04.020. PMID 15946766.
Wakana Y, Koyama S, Nakajima K, et al. (2005). "Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi". Biochem. Biophys. Res. Commun. 334 (4): 1198–205. doi:10.1016/j.bbrc.2005.07.012. PMID 16054885.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ (2010). "Widespread Distribution of Reticulon-3 in Various Neurodegenerative Diseases". Neuropathology. 30 (6): 574–9. doi:10.1111/j.1440-1789.2010.01107.x. PMC 2902651. PMID 20374499.

External links

RTN3 human gene location in the UCSC Genome Browser.
RTN3 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133318 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024758 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10331947-5] Moreira EF, Jaworski CJ, Rodriguez IR (Jul 1999). "Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13". Genomics. 58 (1): 73–81. doi:10.1006/geno.1999.5807. PMID 10331947.

[entrez-6] "Entrez Gene: RTN3 reticulon 3".

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RTN3

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