Her health was delicate throughout her life. According to Walpole, she "never appeared more than an unhealthy child of thirteen or fourteen".[2]
In 1764, negotiations were made between the British and Danish royal houses of a marriage between the Danish heir to the throne, Prince Christian, and a British princess. The marriage was considered suitable in status and welcomed by both houses, as there were few royal Protestant houses to choose between at that point for either party. The preferred choice for a bride was initially Princess Louisa, but after the Danish representative in London, Count Hans Caspar von Bothmer (1727-1787), was informed of her weak constitution, her younger sister Caroline Matilda was chosen for the match instead.[3] The marriage was announced in Great Britain 10 January 1765.[4]
The same year, 1764, she received a proposal from her brother's brother-in-law, Adolf Frederick of Mecklenburg-Strelitz, but negotiations were again deterred due to concerns regarding her health.[5]
Reportedly, by the time her sister Caroline Matilda left Great Britain for Denmark in 1766, Louisa was succumbing to a more and more deteriorating state of health due to an advancing tuberculosis, which eventually turned her into an invalid.[6]
Princess Louisa died, at Carlton House, London, on 13 May 1768, unmarried, and without issue, at the age of 19.
The generations indicate descent from George I, who formalised the use of the titles prince and princess for members of the British royal family. Where a princess may have been or is descended from George I more than once, her most senior descent, by which she bore or bears her title, is used.