Polyoxins

Polyoxin D

Polyoxins are a group of peptidyl nucleoside antibiotics.[1][2] They are a complex produced by Streptomyces cacaoi var. asoensis and S. piomogenus.[3] Polyoxin compounds contain the same base structure but differ in the composition of certain functional groups. At least fifteen polyoxin compounds are known, designated as polyoxin A, B, C and so forth. Polyoxins A through O are known and all except for 'C' and 'I' have fungicidal activity against phytopathogenic fungi.[3] Some polyoxins have been used as agricultural fungicides because of this.

Polyoxins work by inhibiting the biosynthesis of chitin.[4][2]

References

  1. ^ Brock Biology of Microorganisms (2003, Pearson Education Limited) Madigan (et al); pg.708
  2. ^ a b Li, Jine; Li, Lei; Feng, Chi; Chen, Yihua; Tan, Huarong (2012-10-08). "Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes". Microbial Cell Factories. 11 (1): 135. doi:10.1186/1475-2859-11-135. ISSN 1475-2859. PMC 3520715. PMID 23043373.
  3. ^ a b The Merck Index (15th ed.). Royal Society of Chemistry. 2013. p. 1410. ISBN 978-1-84973-670-1.
  4. ^ "Biology of Microorganisms" (2012, Pearson Education Limited) Brock; pg. 777-778


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