Physalin

Physalins are steroidal constituents of Physalis plants which possess an unusual 13,14-seco-16,24-cyclo-steroidal ring skeleton (where the bond that is normally present between the 13 and 14 positions in other steroids is broken while a new bond between positions 16 and 24 is formed; see figure below).[1] Since the isolation and the structure determination of Physalin A and Physalin B in 1969, more than a dozen Physalins were isolated from Physalis species, Physalis alkekengi, Physalis angulata, and Physalis lancifolia. These compounds have antimicrobial,[2][3] and antiparasitic effects.[4]

Chemical structures of Physalins A and B (left and middle respectively) and of the prototypical steroid ring skeleton (right) in which the atoms in the latter are numbered for reference. Ring bonds that differ between typical steroids and the physalins are represented by a wavy line (bond breaking) and a dashed line (bond forming).

References

  1. ^ Matsuura T, Kawai M, Makashima R, Butsugan Y (1970). "Structures of physalin A and physalin B, 13,14-seco-16,24-cyclo-steroids from Physalis alkekengi var. Francheti". J. Chem. Soc. Perkin Trans. 1. 5 (5): 664–70. doi:10.1039/j39700000664. PMID 5461642.
  2. ^ Januário AH, Filho ER, Pietro RC, Kashima S, Sato DN, França SC (2002). "Antimycobacterial physalins from Physalis angulata L. (Solanaceae)". Phytother Res. 16 (5): 445–8. doi:10.1002/ptr.939. PMID 12203265. S2CID 20323658.
  3. ^ Silva MT, Simas SM, Batista TG, Cardarelli P, Tomassini TC (2005). "Studies on antimicrobial activity, in vitro, of Physalis angulata L. (Solanaceae) fraction and physalin B bringing out the importance of assay determination". Mem. Inst. Oswaldo Cruz. 100 (7): 779–82. doi:10.1590/S0074-02762005000700018. hdl:1807/8334. PMID 16410969.
  4. ^ Choudhary MI, Yousaf S, Ahmed S, Yasmeen K (2005). "Antileishmanial physalins from Physalis minima". Chemistry & Biodiversity. 2 (9): 1164–73. doi:10.1002/cbdv.200590086. PMID 17193198. S2CID 20648658.

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