en Phosphomevalonate kinase

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Phosphomevalonate kinase
Phosphomevalonate kinase
Identifiers
EC no.	2.7.4.2
CAS no.	9026-46-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

PMVK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CH4
Identifiers
Aliases	PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDs	OMIM: 607622; MGI: 1915853; HomoloGene: 4779; GeneCards: PMVK; OMA:PMVK - orthologs
EC number	2.7.4.2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,936,719 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,376,320 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lobe of liver; ; anterior pituitary; ; nucleus accumbens; ; C1 segment; ; skin of abdomen; ; anterior cingulate cortex; ; skin of leg; ; right adrenal cortex; ; right auricle;
	Top expressed in
	fossa; ; lip; ; condyle; ; motor neuron; ; facial motor nucleus; ; trigeminal ganglion; ; ectoderm; ; otic placode; ; supraoptic nucleus; ; otic vesicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; kinase activity; phosphomevalonate kinase activity;
Cellular component	cytoplasm; cytosol; peroxisome; extracellular exosome; membrane;
Biological process	cholesterol biosynthetic process; steroid metabolic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; response to cholesterol; cholesterol metabolic process; sterol biosynthetic process; isoprenoid biosynthetic process; phosphorylation; lipid metabolism; steroid biosynthetic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10654
	68603
	ENSG00000163344
	ENSMUSG00000027952
	Q15126
	Q9D1G2
	NM_006556; NM_001323011; NM_001323012; NM_001348696
	NM_026784; NM_027348; NM_001310640
	NP_001309940; NP_001309941; NP_006547; NP_001335625
	NP_001297569; NP_081060; NP_081624
	Wikidata
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Phosphomevalonate kinase

Identifiers

Symbol

PMVK

Other data

Chr. 1 p13-q23

Search for
Structures	Swiss-model
Domains	InterPro

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway^[5]^[6]^[7] that in humans is encoded by the PMVK gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.
^ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
^ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

External links

Phosphomevalonate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q15126 (Phosphomevalonate kinase) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.

[6] Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.

[7] Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

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