PIGU

PIGU
Identifiers
AliasesPIGU, CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U, GPIBD21, NEDBSS
External IDsOMIM: 608528; MGI: 3039607; HomoloGene: 6553; GeneCards: PIGU; OMA:PIGU - orthologs
Orthologs
SpeciesHumanMouse
Entrez

128869

228812

Ensembl

ENSG00000101464

ENSMUSG00000038383

UniProt

Q9H490

Q3TAA8

RefSeq (mRNA)

NM_080476

NM_001004721

RefSeq (protein)

NP_536724

NP_001004721

Location (UCSC)Chr 20: 34.56 – 34.7 MbChr 2: 155.12 – 155.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.[5][6][7]

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101464 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038383 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076. PMID 12802054.
  6. ^ Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568. S2CID 900186.
  7. ^ a b "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U".

Further reading

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