en Olfactory marker protein

Olfactory marker protein
Olfactory marker protein
	solution structure of olfactory marker protein from rat
Identifiers
Symbol	Olfactory_mark
Pfam	PF06554
InterPro	IPR009103
SCOP2	1jyt / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.^[1] Three highly conserved regions have been identified as possible protein–protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.^[2]

External links

Olfactory+marker+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

^ Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873.
^ Smith PC, Firestein S, Hunt JF (June 2002). "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21. doi:10.1016/S0022-2836(02)00242-5. PMID 12054872.

This article incorporates text from the public domain Pfam and InterPro: IPR009103

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