NOLA2

NHP2
Identifiers
AliasesNHP2, DKCB2, NHP2P, NOLA2, NHP2 ribonucleoprotein
External IDsOMIM: 606470; MGI: 1098547; HomoloGene: 5524; GeneCards: NHP2; OMA:NHP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

55651

52530

Ensembl

ENSG00000145912

ENSMUSG00000001056

UniProt

Q9NX24

Q9CRB2

RefSeq (mRNA)

NM_017838
NM_001034833
NM_001396110

NM_026631
NM_001364736

RefSeq (protein)

NP_001030005
NP_060308

NP_080907
NP_001351665

Location (UCSC)Chr 5: 178.15 – 178.15 MbChr 11: 51.51 – 51.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.[5][6]

Identifiers

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.

The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145912 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001056 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pogacic V, Dragon F, Filipowicz W (Dec 2000). "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10". Mol Cell Biol. 20 (23): 9028–40. doi:10.1128/MCB.20.23.9028-9040.2000. PMC 86556. PMID 11074001.
  6. ^ a b "Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)".

Further reading


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