Monoterpene epsilon-lactone hydrolase

The enzyme monoterpene ε-lactone hydrolase (EC 3.1.1.83, MLH; systematic name isoprop(en)ylmethyloxepan-2-one lactonohydrolase^[1] catalyses the reaction

(1) isoprop(en)ylmethyloxepan-2-one + H₂O ${\displaystyle \rightleftharpoons }$ 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction)

(2) 4-isopropenyl-7-methyloxepan-2-one + H₂O ${\displaystyle \rightleftharpoons }$ 6-hydroxy-3-isopropenylheptanoate

(3) 7-isopropyl-4-methyloxepan-2-one + H₂O ${\displaystyle \rightleftharpoons }$ 6-hydroxy-3,7-dimethyloctanoate

The enzyme catalyses the ring opening of ε-lactones in Gram-positive bacterium Rhodococcus erythropolis DCL14.

• Monoterpene+epsilon-lactone+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)