The Missouri Republican Party is the affiliate of the United States Republican Party in Missouri. Its chair is Nick Myers, who has served since 2021. It is currently the dominant party in the state, controlling the majority of Missouri's U.S. House seats, both U.S. Senate seats, both houses of the state legislature, and all statewide offices, including the governorship.
Blair and other Unionists in Missouri supported the removal of John C. Frémont's military command and the rescinding of his emancipation order. However, B. Gratz Brown, the former chair, supported Frémont. Blair and Brown disagreed on gradual compensated emancipation and slave colonization with Blair in support and Brown in opposition.[2]