Miniprotein

X-ray crystal structure of the first de novo designed disulfide-rich miniprotein gEHEE_06. PDB: 5JG9​

A miniprotein is a type of peptide, characterized by the presence of protein tertiary structure.[1] In nature, they are commonly found in the venom of animals[2] such as scorpions,[3] spiders,[4] and cone snails.[5] It is also possible to create miniproteins de novo using protein design.[6]

References

  1. ^ Crook ZR, Nairn NW, Olson JM (2021). "Miniproteins as a Powerful Modality in Drug Development". Trends Biochem Sci. 45 (4): 332–346. doi:10.1016/j.tibs.2019.12.008. PMC 7197703. PMID 32014389.
  2. ^ Lewis RJ, Garcia ML (2003). "Therapeutic potential of venom peptides". Nat Rev Drug Discov. 2 (10): 790–802. Bibcode:2003NRvDD...2..790L. doi:10.1038/nrd1197. PMID 14526382.
  3. ^ Xia Z, He D, Wu Y, KWOK HF, Cao Z (2023). "Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers". Pharmacol Res. 197 (106978) 106978. doi:10.1016/j.phrs.2023.106978. PMID 37923027.
  4. ^ Langenegger N, Nentwig W, Kuhn-Nentwig L (2019). "Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses". Toxins. 11 (10): 611. doi:10.3390/toxins11100611. PMC 6832493. PMID 31652611.
  5. ^ Li R, Yu J, Ye D, Liu S, Zhang H, Lin H, Feng J, Deng K (2025). "Conotoxins: Classification, Prediction, and Future Directions in Bioinformatics". Toxins. 17 (2): 78. doi:10.3390/toxins17020078. PMC 11860864. PMID 39998095.
  6. ^ Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Griesen P, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D (2016). "Accurate de novo design of hyperstable constrained peptides". Nature. 538 (7625): 329–335. Bibcode:2016Natur.538..329B. doi:10.1038/nature19791. PMC 5161715. PMID 27626386.

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