MicroRNA 495
| MIR495 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR495, MIRN495, hsa-mir-495, mir-495, microRNA 495 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 615149; GeneCards: MIR495; OMA:MIR495 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene. [3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000207743 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: MicroRNA 495". Retrieved 2018-01-07.
Further reading
- Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH (2011). "miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1". Oncogene. 30 (21): 2463–74. doi:10.1038/onc.2010.618. PMID 21258409.
- Li Z, Cao Y, Jie Z, Liu Y, Li Y, Li J, Zhu G, Liu Z, Tu Y, Peng G, Lee DW, Park SS (2012). "miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3". Cancer Lett. 323 (1): 41–7. doi:10.1016/j.canlet.2012.03.029. PMID 22469786.
- Jiang X, Huang H, Li Z, He C, Li Y, Chen P, Gurbuxani S, Arnovitz S, Hong GM, Price C, Ren H, Kunjamma RB, Neilly MB, Salat J, Wunderlich M, Slany RK, Zhang Y, Larson RA, Le Beau MM, Mulloy JC, Rowley JD, Chen J (2012). "MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia". Proc. Natl. Acad. Sci. U.S.A. 109 (47): 19397–402. Bibcode:2012PNAS..10919397J. doi:10.1073/pnas.1217519109. PMC 3511140. PMID 23132946.
- Chen SM, Chen HC, Chen SJ, Huang CY, Chen PY, Wu TW, Feng LY, Tsai HC, Lui TN, Hsueh C, Wei KC (2013). "MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6". World J Surg Oncol. 11: 87. doi:10.1186/1477-7819-11-87. PMC 3655862. PMID 23594394.
- Song L, Li Y, Li W, Wu S, Li Z (2014). "miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A)". J. Cell. Biochem. 115 (7): 1234–42. doi:10.1002/jcb.24665. PMID 24038379. S2CID 23587479.
- Formosa A, Markert EK, Lena AM, Italiano D, Finazzi-Agro' E, Levine AJ, Bernardini S, Garabadgiu AV, Melino G, Candi E (2014). "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells". Oncogene. 33 (44): 5173–82. doi:10.1038/onc.2013.451. PMID 24166498. S2CID 36638076.
- Chu H, Chen X, Wang H, Du Y, Wang Y, Zang W, Li P, Li J, Chang J, Zhao G, Zhang G (2014). "MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3". Tumour Biol. 35 (4): 3487–94. doi:10.1007/s13277-013-1460-1. PMID 24293376. S2CID 15816727.
- Xu Y, Ohms SJ, Li Z, Wang Q, Gong G, Hu Y, Mao Z, Shannon MF, Fan JY (2013). "Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance". PLOS ONE. 8 (11) e82062. Bibcode:2013PLoSO...882062X. doi:10.1371/journal.pone.0082062. PMC 3841137. PMID 24303078.
- Lee S, Yoon DS, Paik S, Lee KM, Jang Y, Lee JW (2014). "microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9". Stem Cells Dev. 23 (15): 1798–808. doi:10.1089/scd.2013.0609. PMC 4103260. PMID 24654627.
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