Margaret was the second child of her father's first marriage. She was betrothed at the age of two to Amadeus VI, Count of Savoy, the contract being signed on 7 March 1338.[2] The contract was, however, broken and Amadeus married Margaret's cousin, Bonne of Bourbon.[3]
The marriage lasted seven years and no children were born of the union, probably because of Margaret's young age. She died in 1349 while still a minor, aged around fourteen, and was probably buried in Székesfehérvár Basilica. She had outlived her mother, Blanche, by only one year. Her husband remarried four years later to Elizabeth of Bosnia.