en Mangostin

Mangostin
Names
	Preferred IUPAC name 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
	Other names alpha-mangostin
Identifiers
CAS Number	6147-11-1 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:67547 ;
ChEMBL	ChEMBL323197 ;
ChemSpider	4444969 ;
ECHA InfoCard	100.208.637
PubChem CID	5281650;
UNII	U6RIV93RU1 ;
CompTox Dashboard (EPA)	DTXSID00210420 ;
	InChI InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3 Key: GNRIZKKCNOBBMO-UHFFFAOYSA-N ; InChI=1/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3 Key: GNRIZKKCNOBBMO-UHFFFAOYAL;
	SMILES CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C)C)O)C;
Properties
Chemical formula	C24H26O6
Molar mass	410.466 g·mol−1
Appearance	Yellow crystalline solid
Density	1.265 g/ml
Melting point	182 °C (360 °F; 455 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure.

Source

The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. Researchers conducted the optimization steps in order to increase the yield of α-mangostin extraction from the pericarp of the mangosteen and was able to achieve 9.2 g/kg DW.^[1] The rind of fully ripe fruits also contains the xanthonoids gartanin, 8-disoxygartanin, and normangostin.^{[citation needed]}

Research

Mangostin and a variety of other xanthonoids from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.^[2]

In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.^[3]^{[better source needed]}

Related compounds

A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.^{[citation needed]}

References

^ Khaw, Kooi Yeong; Ong, Yong Sze; Goh, Bey-Hing (2020). "A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin". Progress in Drug Discovery & Biomedical Science. 3 (1). doi:10.36877/pddbs.a0000072.
^ Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578.
^ Shankaranarayan D, Gopalakrishnan C, Kameswaran L (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.

[1] Khaw, Kooi Yeong; Ong, Yong Sze; Goh, Bey-Hing (2020). "A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin". Progress in Drug Discovery & Biomedical Science. 3 (1). doi:10.36877/pddbs.a0000072.

[2] Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578.

[3] Shankaranarayan D, Gopalakrishnan C, Kameswaran L (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.

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