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LTBP2
Identifiers
Aliases	LTBP2, C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3, latent transforming growth factor beta binding protein 2
External IDs	OMIM: 602091; MGI: 99502; HomoloGene: 369; GeneCards: LTBP2; OMA:LTBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,612,378 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,923,306 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; stromal cell of endometrium; ; right coronary artery; ; tendon of biceps brachii; ; saphenous vein; ; pericardium; ; left coronary artery; ; popliteal artery; ; tibial arteries;
	Top expressed in
	aortic valve; ; ascending aorta; ; rib; ; stroma of bone marrow; ; vestibular membrane of cochlear duct; ; external carotid artery; ; left lung lobe; ; brown adipose tissue; ; ciliary body; ; calvaria;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; heparin binding; protein binding; growth factor binding; extracellular matrix structural constituent; microfibril binding;
Cellular component	extracellular matrix; extracellular exosome; intracellular anatomical structure; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	protein targeting; transforming growth factor beta receptor signaling pathway; protein secretion; supramolecular fiber organization;
	Sources:Amigo / QuickGO
Orthologs
	4053
	16997
	ENSG00000119681
	ENSMUSG00000002020
	Q14767
	O08999
	NM_000428
	NM_013589; NM_001370743
	NP_000419
	NP_038617; NP_001357672
	Wikidata
View/Edit Human	View/Edit Mouse

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.^[5]^[6]

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins.

It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119681 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem. 269 (51): 32469–78. doi:10.1016/S0021-9258(18)31659-4. PMID 7798248.
^ ^a ^b "Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2".

Chambaz EM, Souchelnitskiy S, Pellerin S, et al. (1996). "Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical cell endocrine functions". Horm. Res. 45 (3–5): 222–6. doi:10.1159/000184792. PMID 8964588.
Munger JS, Harpel JG, Gleizes PE, et al. (1997). "Latent transforming growth factor-beta: structural features and mechanisms of activation". Kidney Int. 51 (5): 1376–82. doi:10.1038/ki.1997.188. PMID 9150447.
Taipale J, Saharinen J, Keski-Oja J (1998). "Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion". Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion. Advances in Cancer Research. Vol. 75. pp. 87–134. doi:10.1016/S0065-230X(08)60740-X. ISBN 978-0-12-006675-9. PMID 9709808. {{cite book}}: |journal= ignored (help)
Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3 (3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
Li X, Yin W, Pérez-Jurado L, et al. (1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)" (PDF). Mamm. Genome. 6 (1): 42–5. doi:10.1007/BF00350892. hdl:2027.42/47013. PMID 7719025. S2CID 32672633.
Bashir MM, Han MD, Abrams WR, et al. (1996). "Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2". Int. J. Biochem. Cell Biol. 28 (5): 531–42. doi:10.1016/1357-2725(95)00167-0. PMID 8697098.
Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J (1998). "Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release". J. Biol. Chem. 273 (32): 20669–76. doi:10.1074/jbc.273.32.20669. PMID 9685426.
Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
Wu X, Blanck A, Norstedt G, et al. (2002). "Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium". Mol. Hum. Reprod. 8 (3): 246–54. doi:10.1093/molehr/8.3.246. PMID 11870232.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Vehviläinen P, Hyytiäinen M, Keski-Oja J (2003). "Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells". J. Biol. Chem. 278 (27): 24705–13. doi:10.1074/jbc.M212953200. PMID 12716902.
Hirani R, Hanssen E, Gibson MA (2007). "LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein". Matrix Biol. 26 (4): 213–23. CiteSeerX 10.1.1.328.5118. doi:10.1016/j.matbio.2006.12.006. PMID 17293099.

External links

GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119681 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7798248-5] Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem. 269 (51): 32469–78. doi:10.1016/S0021-9258(18)31659-4. PMID 7798248.

[entrez-6] "Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2".

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LTBP2

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