LSM7

LSM7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM7, YNL147W, LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsOMIM: 607287; MGI: 1913344; HomoloGene: 6781; GeneCards: LSM7; OMA:LSM7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

51690

66094

Ensembl

ENSG00000130332

ENSMUSG00000035215

UniProt

Q9UK45

Q9CQQ8

RefSeq (mRNA)

NM_016199

NM_025349
NM_001359148
NM_001359149
NM_001359150

RefSeq (protein)

NP_057283

NP_079625
NP_001346077
NP_001346078
NP_001346079

Location (UCSC)Chr 19: 2.32 – 2.33 MbChr 10: 80.69 – 80.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.[5][6][7]

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

Interactions

LSM7 has been shown to interact with TACC1[8][9] and LSM2.[10][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130332 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035215 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  6. ^ Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (Dec 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
  7. ^ a b "Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  8. ^ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
  9. ^ Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
  10. ^ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  11. ^ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

Further reading


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