In January 2019, he joined Premier League club Manchester City and was immediately loaned to Eredivisie club Groningen, until the summer of 2020.[4] On 24 July 2020, his stay with Groningen was extended with one more year after both clubs agreed.[5]
On 19 August 2021, Itakura signed a season-long loan deal with 2. Bundesliga club Schalke 04 with an option to make the move permanent for £5 million.[6] At the end of the season, he was promoted to the Bundesliga with Schalke, but the club did not activate the option due to financial reasons.[7]
On August 19 2023, he scored his first goal in the Bundesliga against Augsburg, and on September 2, he scored a goal against Bayern Munich, which had the most wins and were the champions of the previous year.[8] On September 8th, he was selected as the team's MVP for August.[9]
In November 2022, he was selected for the 2022 FIFA World Cup Japan National team for the first time.[12] Participated in all group stage matches and became the first Asian team to win first place in an overseas World Cup group league, contributing to advance to the final tournament for two consecutive tournaments. His long ball was the starting point of the come-from-behind goal against Germany. He was also named in the first group stage best eleven by Spain's 'Marca' and Italy's version of 'Sky Sports'.[13] The former named him one of the players to double his value in the World Cup and described him as "the most consistent performance of the entire tournament".[14]
On March 28, 2023, he served as captain for the first time in the second match of the second term of MoriyasuJapan against Colombia.[15]