KDP34

KDP34
Chemical and physical data
FormulaC74H97N15O22
Molar mass1548.673 g·mol−1
3D model (JSmol)
  • O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[NH]c2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(=O)N)C(O)=O)C(C)C)[C@H](O)C)[C@@H](N)CC(=O)O
  • InChI=InChI=1S/C74H97N15O22/c1-37(2)28-50(66(102)83-53(31-42-20-22-44(92)23-21-42)70(106)88-61(38(3)4)72(108)80-49(25-27-59(95)96)64(100)86-55(74(110)111)34-58(77)94)82-68(104)52(30-41-16-10-7-11-17-41)84-71(107)56(36-90)87-69(105)54(32-43-35-78-47-19-13-12-18-45(43)47)85-73(109)62(39(5)91)89-65(101)48(24-26-57(76)93)79-67(103)51(29-40-14-8-6-9-15-40)81-63(99)46(75)33-60(97)98/h6-23,35,37-39,46,48-56,61-62,78,90-92H,24-34,36,75H2,1-5H3,(H2,76,93)(H2,77,94)(H,79,103)(H,80,108)(H,81,99)(H,82,104)(H,83,102)(H,84,107)(H,85,109)(H,86,100)(H,87,105)(H,88,106)(H,89,101)(H,95,96)(H,97,98)(H,110,111)/t39-,46+,48+,49+,50+,51+,52+,53+,54+,55+,56+,61+,62+/m1/s1
  • Key:HIUFCNAPIWVDMP-CTLYRQNCSA-N

KDP34 is a dodecapeptide with the sequence DFQTWSFLYVEN or Asp-Phe-Gln-Thr-Trp-Ser-Phe-Leu-Tyr-Val-Glu-Asn. It is a knuckle epitope peptide that is a modified fragment of bone morphogenetic protein 2 (BMP-2), with similar effects and higher potency. Recombinant BMP-2 is used clinically to enhance healing of bones, such as in bone transplants or bone grafts, but needs to be used very carefully due to side effects such as inflammation and inappropriate bone growth in non targeted tissues. Modified peptide analogues of BMP-2 such as KDP34 have been developed as potential alternatives which may show more selectivity and an improved side effect profile.[1]

References

  1. ^ Zhang W, Liu J, Shan H, Yin F, Zhong B, Zhang C, et al. (2020). "Machine learning-guided evolution of BMP-2 knuckle Epitope-Derived osteogenic peptides to target BMP receptor II". Journal of Drug Targeting. 28 (7–8): 802–810. doi:10.1080/1061186X.2020.1757100. PMID 32354236.

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