en HBG2

HBG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FDH, 4MQJ, 4MQK
Identifiers
Aliases	HBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2
External IDs	OMIM: 142250; MGI: 96027; HomoloGene: 128032; GeneCards: HBG2; OMA:HBG2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,505,605 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	103,502,423 bp
RNA expression pattern
	Top expressed in
	placenta; ; ganglionic eminence; ; ventricular zone; ; blood; ; monocyte; ; bone marrow; ; bone marrow cells; ; apex of heart; ; spleen; ; lung;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; endocardial cushion; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; somite; ; hand; ; human fetus; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxygen carrier activity; heme binding; metal ion binding; oxygen binding; peroxidase activity; protein binding; haptoglobin binding; organic acid binding;
Cellular component	blood microparticle; hemoglobin complex; cytosol; haptoglobin-hemoglobin complex;
Biological process	oxygen transport; blood coagulation; transport; hydrogen peroxide catabolic process; protein heterooligomerization; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3048
	15135
	ENSG00000196565
	ENSMUSG00000052187
	P69892
	P02104
	NM_000184
	NM_008221
	NP_000175
	NP_032247
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.^[5]

Function

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.^[6]