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Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules...

release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha and Fas ligand, also...

somatic cells, TC cells release the cytotoxins perforin, granzymes, and granulysin. Through the action of perforin, granzymes enter the cytoplasm of the...

allowing ions, water and toxins to enter. The entry of another toxin called granulysin (a protease) induces the target cell to undergo apoptosis. T cell killing...

Krensky AM, Mody CH (September 2004). "NK cells use perforin rather than granulysin for anticryptococcal activity". Journal of Immunology. 173 (5): 3357–3365...

Granule Defensins TLR4 Cathelicidin (LL37) P2X7, FPR2 Eosinophil-derived neurotoxin TLR2 Granulysin TLR4 Plasma membrane Syndecans TLR4 Glypicans TLR4...

member of the SAPLIP (saposin-like protein) family along with amoebapore, granulysin, acid sphingomyelinase, surfactant protein B, and the 4 sphingolipid activator...

drug-modified peptide–HLA or drug–HLA/TCR complexes. Perforin/granzyme and granulysin induce keratinocyte apoptosis/necrosis. Epidermal injury can become widespread...

Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D (2003). "Granulysin crystal structure and a structure-derived lytic mechanism". J. Mol. Biol...

involved in immune system defense against microbial disease (example: granulysin is protective against Mycobacterium tuberculosis ) or are targeted receptors...

infected or dysfunctional somatic cells, effector CTLs release perforin and granulysin: cytotoxins that form pores in the target cell's plasma membrane, allowing...

drug-induced release of AGEP mediators (e.g. interferon-γ interleukin 4, or granulysin) are measured have likewise not been broadly adopted because of their...

allowing ions, water and toxins to enter. The entry of another toxin called granulysin induces the target cell to undergo apoptosis. Helper T cells and regulatory...

et al. (June 2014). "Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes". Cell. 157 (6): 1309–23. doi:10.1016/j...

able to kill keratinocytes. Cytotoxic molecules (granzyme B, perforin, granulysin) can be detected in vivo in blood and the blister fluid in the first few...

cytotoxic factors like the granzymes GZMA, GZMB, GZMH, perforin PRF1, and granulysin GNLY. Chemokine ligands CXCL9, CXCL10, and CCL5 that bind to chemokine...

cell-injuring proteins made by CD8+ and natural killer cells, (viz., granulysin, granzyme B, and perforin); and two cytokines that stimulate the proliferation...

contain pore-forming protein perforin and apoptosis-inducing proteins granulysin and granzyme. The KHYG-1 cells show superior cytotoxic activity against...

activity of cytolytic T cells mediated by granulysin. Science 1998; 282: 121-125. Pena SV, Krensky AM: Granulysin, a new human cytolytic granule associated...

colony-stimulating factor Granulocyte macrophage colony-stimulating factor receptor Granulysin Granzyme Growth factor Gut-associated lymphoid tissue H-Y antigen Hapten...

binding to the membrane. Notable members of the SAPLIP family include granulysin (antimicrobial), pulmonary surfactant-associated protein B (pulmonary...