The film followed by a sequel, Gang of Roses II: Next Generation (2012).
Plot
The film starts off with Left Eye Watkins and his gang attempting to bully Sheriff Shoeshine Michel into giving them gold and women. A female member of the gang is extremely enthusiastic about the women and sets out to rape a can-can girl in the middle of town. While resisting, the can-can cuts the female gang member who in turns shoots her in the middle of the road.
The can-can girl happens to be the sister of Rachel (Calhoun), the protagonist. Rachel, a religious, reformed bad girl, rounds up her former gang members, Kim (Dash), Zang Li (Matiko), Chastity (Lil' Kim), Maria (LisaRaye), and Frankie (Sánchez) to seek revenge. They are followed by a blacked haired lady who is also seeking revenge upon Chastity.