GSTO1
Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.[5][6][7]
This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.[7] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148834 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025068 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, et al. (Sep 2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases". J Biol Chem. 275 (32): 24798–806. doi:10.1074/jbc.M001706200. PMID 10783391.
- ^ Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID 12618591.
- ^ a b "Entrez Gene: GSTO1 glutathione S-transferase omega 1".
- ^ Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG (2005). "Characterization of the Omega Class of Glutathione Transferases". Gluthione Transferases and Gamma-Glutamyl Transpeptidases. Methods in Enzymology. Vol. 401. pp. 78–99. doi:10.1016/S0076-6879(05)01005-0. ISBN 978-0-12-182806-6. PMID 16399380.
Further reading
- Matoba R, Okubo K, Hori N, Atsushi F, Kenichi M (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
- Ishikawa T, Casini AF, Nishikimi M (1998). "Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase". J. Biol. Chem. 273 (44): 28708–12. doi:10.1074/jbc.273.44.28708. PMID 9786866.
- Kodym R, Calkins P, Story M (1999). "The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins". J. Biol. Chem. 274 (8): 5131–7. doi:10.1074/jbc.274.8.5131. PMID 9988762.
- Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping". Electrophoresis. 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497. S2CID 42538820.
- Yin ZL, Dahlstrom JE, Le Couteur DG, Board PG (2001). "Immunohistochemistry of omega class glutathione S-transferase in human tissues". J. Histochem. Cytochem. 49 (8): 983–7. doi:10.1177/002215540104900806. PMID 11457926.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tanaka-Kagawa T, Jinno H, Hasegawa T, Makino Y, Seko Y, Hanioka N, et al. (2003). "Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn)". Biochem. Biophys. Res. Commun. 301 (2): 516–20. doi:10.1016/S0006-291X(02)03066-8. PMID 12565892.
- Yu L, Kalla K, Guthrie E, Vidrine A, Klimecki WT (2004). "Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans". Environ. Health Perspect. 111 (11): 1421–7. doi:10.1289/ehp.6420. PMC 1241635. PMID 12928150.
- Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR, et al. (2004). "Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease". Hum. Mol. Genet. 12 (24): 3259–67. doi:10.1093/hmg/ddg357. PMID 14570706.
- Whitbread AK, Mellick GD, Silburn PA, Le Couteur DG, Board PG (2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease". Neurology. 62 (10): 1910–1. doi:10.1212/01.wnl.0000125282.09308.b1. PMID 15159516. S2CID 46505059.
- Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kölsch H, Linnebank M, Lütjohann D, Jessen F, Wüllner U, Harbrecht U, et al. (2005). "Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke". Neurology. 63 (12): 2255–60. doi:10.1212/01.wnl.0000147294.29309.47. PMID 15623683. S2CID 21431373.
- Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiol. Aging. 26 (8): 1161–5. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099. S2CID 10878355.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Fujihara J, Kunito T, Takeshita H (2007). "Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method". Clin. Chem. Lab. Med. 45 (5): 621–4. doi:10.1515/CCLM.2007.128. PMID 17484623. S2CID 1553700.
- Harju TH, Peltoniemi MJ, Rytilä PH, Soini Y, Salmenkivi KM, Board PG, et al. (2007). "Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients". Respir. Res. 8 (1): 48. doi:10.1186/1465-9921-8-48. PMC 1939846. PMID 17617905.
- Kölsch H, Larionov S, Dedeck O, Orantes M, Birkenmeier G, Griffin WS, et al. (2007). "Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression". Stroke. 38 (10): 2847–50. doi:10.1161/STROKEAHA.107.484162. PMID 17717316.
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