He obtained a doctorate in utroque iure, both canon and civil law from the University of Fermo. He served as Vice-legate in Fermo, and was made a domestic prelate 25 November 1688. The following year, he was appointed Vice-legate in Ferrara. Francesco Acquaviva was consecrated titular archbishop of Larissa 22 December 1697.[2] Francesco Acquaviva filled various offices under Popes Innocent XI, Alexander VIII, Innocent XII, and Clement XI, who created him Cardinal in the consistory of 17 May 1706.
He was nuncio to Spain, from 6 April 1700 until 7 December 1706. In 1708, due to the Austrian conquest of the Kingdom of Naples, he lost a number of ecclesiastical benefices, but was compensated by Philip V with the appointment as diplomatic representative of the Catholic court to the Holy See, as well as cardinal protector of Spain.[3] He was very loyal to Philip V, and sold his silverware to help the king bear the costs of the long war of succession and, in a critical moment, also saved the first wife of that sovereign, Luisa Maria Gabriella of Savoy. He participated in matters such as arranging the marriage of King Philip V and Princess Isabella Farnese of Parma, on 20 August 1714.[1] He resided at the Palazzo di Spagna in Rome.
In 1709, he was named Cardinal-protector of Santa Cecilia in Trastevere.[1] He served as Camerlengo of the Sacred College of Cardinals from 26 January 1711 until 2 March 1712. Francesco Acquaviva participated in the conclave of 1721, which elected Pope Innocent XIII, and the conclave of 1724, which elected Pope Benedict XIII.[2]
This article incorporates text from a publication now in the public domain: Herbermann, Charles, ed. (1913). "Acquaviva". Catholic Encyclopedia. New York: Robert Appleton Company.