DAPK3
Protein-coding gene in the species Homo sapiens
Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene .[ 5] [ 6]
Function
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[ 6]
Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[ 7]
Interactions
DAPK3 has been shown to interact with PAWR [ 8] and Death associated protein 6 .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000167657 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034974 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis" . Molecular and Cellular Biology . 18 (3): 1642–51. doi :10.1128/mcb.18.3.1642 . PMC 108879 . PMID 9488481 .
^ a b "Entrez Gene: DAPK3 death-associated protein kinase 3" .
^ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene" . PLOS Genetics . 3 (10): 1884–93. doi :10.1371/journal.pgen.0030180 . PMC 2041995 . PMID 17953487 .
^ a b Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains" . Molecular and Cellular Biology . 23 (17): 6174–86. doi :10.1128/MCB.23.17.6174-6186.2003 . PMC 180930 . PMID 12917339 .
Further reading
Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization" . Journal of Human Genetics . 43 (3): 209–11. doi :10.1007/s100380050073 . PMID 9747039 .
Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H (May 1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells" . FEBS Letters . 451 (1): 81–4. doi :10.1016/S0014-5793(99)00550-5 . PMID 10356987 . S2CID 43329315 .
Page G, Lödige I, Kögel D, Scheidtmann KH (Nov 1999). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis" . FEBS Letters . 462 (1–2): 187–91. doi :10.1016/S0014-5793(99)01529-X . PMID 10580117 . S2CID 6061613 .
Page G, Kögel D, Rangnekar V, Scheidtmann KH (Dec 1999). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis" . Oncogene . 18 (51): 7265–73. doi :10.1038/sj.onc.1203170 . PMID 10602480 .
Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF (Oct 2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta" . Molecular and Cellular Biology . 22 (20): 6959–70. doi :10.1128/MCB.22.20.6959-6970.2002 . PMC 139806 . PMID 12242277 .
Preuss U, Landsberg G, Scheidtmann KH (Feb 2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase" . Nucleic Acids Research . 31 (3): 878–85. doi :10.1093/nar/gkg176 . PMC 149197 . PMID 12560483 .
Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains" . Molecular and Cellular Biology . 23 (17): 6174–86. doi :10.1128/MCB.23.17.6174-6186.2003 . PMC 180930 . PMID 12917339 .
Burch LR, Scott M, Pohler E, Meek D, Hupp T (Mar 2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1". Journal of Molecular Biology . 337 (1): 115–28. doi :10.1016/j.jmb.2003.10.081 . PMID 15001356 .
Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME (Oct 2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase" . The Journal of Biological Chemistry . 279 (40): 42055–61. doi :10.1074/jbc.M403676200 . PMID 15292222 .
Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase" . FASEB Journal . 19 (2): 267–9. doi :10.1096/fj.04-1558fje . PMID 15546961 . S2CID 17142907 .
Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L (Jun 2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3" . International Journal of Andrology . 28 (3): 163–70. doi :10.1111/j.1365-2605.2005.00522.x . PMID 15910542 .
Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene" . PLOS Genetics . 3 (10): 1884–93. doi :10.1371/journal.pgen.0030180 . PMC 2041995 . PMID 17953487 .
Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M (Dec 2006). "Novel ZIP kinase isoform lacks leucine zipper" . Archives of Biochemistry and Biophysics . 456 (2): 194–203. doi :10.1016/j.abb.2006.09.026 . PMC 2758612 . PMID 17126281 .
Activity Regulation Classification Kinetics Types