Born in Alicante, Mazón's father of the same name was a haemotologist, who had a street in the city named after him. His maternal grandfather, Alfonso Guixot, was a businessman involved in entertainment; he owned cinemas and a bullring, and was president of Hércules CF football club.[3]
In 2003, under new Valencian president Francisco Camps, Mazón led the Department of Commerce and Consumption. Four years later, following a rift in the People's Party of the Valencian Community (PPCV) between followers of Zaplana and Camps, he was one of the members of the former, more liberal faction that left regional politics and moved into the politics of the Province of Alicante. He served as a councillor in the provincial capital and in the small town of Catral, as well as being director of the Chamber of Commerce and a member of the Provincial Deputation.[4]
Mazón was elected President of the Provincial Deputation of Alicante in July 2019, receiving support from Citizens to be the fifth consecutive PP president since 1995.[5] A year later, he received 98% of the votes to lead the PP branch in his province.[6] In July 2021, he succeeded Isabel Bonig as leader on a regional level.[7] In the 2023 Valencian regional election, his party came first with 40 seats, up from 19.[8] The PP formed government with the 13 deputies from Vox, on the terms of the PP's national leadership that the government would exclude Vox leader Carlos Flores, who was convicted of harassing his ex-wife in 2002.[9]