en CDH6

CDH6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LND
Identifiers
Aliases	CDH6, CAD6, KCAD, cadherin 6
External IDs	OMIM: 603007; MGI: 107435; HomoloGene: 21027; GeneCards: CDH6; OMA:CDH6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	31,329,146 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	13,173,761 bp
RNA expression pattern
	Top expressed in
	beta cell; ; kidney tubule; ; tibial arteries; ; human kidney; ; endothelial cell; ; vena cava; ; gallbladder; ; sural nerve; ; lateral nuclear group of thalamus; ; metanephric glomerulus;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; hair follicle; ; ascending aorta; ; aortic valve; ; Rostral migratory stream; ; renal corpuscle; ; efferent ductule; ; ciliary body; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	integral component of membrane; plasma membrane; membrane; cell surface; catenin complex;
Biological process	Notch signaling pathway; cell adhesion; adherens junction organization; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell junction assembly; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; cell-cell adhesion; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1004
	12563
	ENSG00000113361
	ENSMUSG00000039385
	P55285
	P97326
	NM_004932; NM_001362435
	NM_007666
	NP_004923; NP_001349364
	NP_031692
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.^[5]^[6]^[7]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113361 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039385 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID 7743525.
^ Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
^ ^a ^b "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

External links

CDH6 human gene location in the UCSC Genome Browser.
CDH6 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113361 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039385 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7743525-5] Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID 7743525.

[pmid10191097-6] Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.

[entrez-7] "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

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CDH6

References

Further reading

External links