Kirkmeyer served for a total of 19 years as a County Commissioner for Weld County, Colorado, having been elected and re-elected five times. Representing the third district, she served from 1993 to 2000 and again from 2009 to 2020. In the interim, Kirkmeyer served as acting director of the Colorado Department of Local Affairs under Colorado GovernorBill Owens. In addition, she has served on several boards and commissions, including the Fort Lupton Urban Renewal Authority Board and the Dacono Urban Renewal Authority Board.
In the 2020 Republican primary election for Colorado's 23rd Senate district, Kirkmeyer defeated opponent Rupert Parchment, winning 55.24% of the votes cast.[5] In the 2020 general election, Kirkmeyer defeated her Democratic Party opponent, winning 55.14% of the votes cast.[6] She currently serves on the Senate Education, Local Government, Health and Human Services, and Statutory Revision Committees. She is also Vice Chair of the Legislative Interim Committee on School Finance.[7]
On November 15, 2021, Kirkmeyer announced she was running to represent Colorado's new 8th congressional district.[8] On June 28, 2022, she won the Republican primary and advanced to the November general election ultimately losing to Democratic opponent, Yadira Caraveo.[9]
During Kirkmeyer's campaign, she notably removed her stances on abortion from her website. She is one of Colorado's most anti-abortion lawmakers, supporting banning the procedure and some forms of contraception and celebrating the overturning of Roe v. Wade.[10] She did not have to give up her state senate seat to run for Congress; Colorado state senators serve staggered four-year terms, and Kirkmeyer was not up for reelection until 2024.