Histopathology of a calcifying aponeurotic fibroma from a finger, H&E stain.
Aponeurotic fibroma, also known as calcifying aponeurotic fibroma, and juvenile aponeurotic fibroma is characterized by a lesion that usually presents as a painless, solitary, deep fibrousnodule, often adherent to tendon, fascia, or periosteum, on the hands and feet.[1]The World Health Organization in 2020 reclassified aponeurotic fibroma nodules as a specific benign type of the fibroblastic and myofibroblastic tumors.[2] Aponeurotic fibromas are diagnosed based on histopathology and treated by surgical excision. They are more common in males than females.
Signs and symptoms
Aponeurotic fibroma occurs most frequently in the fingers, palms, and soles of the distal extremities.[3] Typically, the tumor is defined as a smaller than 3 cm diameter, firm, non-tender mass that grows slowly. It is prone to infiltrate the surrounding tissue and, following surgical resection, is more likely to recur locally.[4]
Diagnosis
A histological examination is necessary to make a diagnosis.[5] Histologically, the tumor is characterized by fibroblast growth and calcification.[3]
Imaging results include edematous alterations and subcutaneous neoplastic tumors with hazy margins that appear to be encroaching on the surrounding tissues. The fascia and tendon sheath are next to the tumor. While T2WI displays heterogeneous signals, T1WI displays signals that are hypointense to isointense. Additionally, there is heterogeneous contrast enhancement.[6][7][8]
Treatment
The treatment of choice for an aponeurotic fibroma is surgical excision.[5]
Epidemiology
Aponeurotic fibroma is a rare tumor. The tumor often manifests in the first or second decade of life, while examples have been documented at birth and 67 years of age. Patients who are male are impacted twice as frequently as those who are female.[4]
^Morii, Takeshi; Yoshiyama, Akira; Morioka, Hideo; Anazawa, Ukei; Mochizuki, Kazuo; Yabe, Hiroo (2008). "Clinical significance of magnetic resonance imaging in the preoperative differential diagnosis of calcifying aponeurotic fibroma". Journal of Orthopaedic Science. 13 (3). Elsevier BV: 180–186. doi:10.1007/s00776-008-1226-6. ISSN0949-2658.
^NISHIO, JUN; INAMITSU, HIDEAKI; IWASAKI, HIROSHI; HAYASHI, HIROYUKI; NAITO, MASATOSHI (2014-07-11). "Calcifying aponeurotic fibroma of the finger in an elderly patient: CT and MRI findings with pathologic correlation". Experimental and Therapeutic Medicine. 8 (3). Spandidos Publications: 841–843. doi:10.3892/etm.2014.1838. ISSN1792-0981.
^Takaku, Mitsuru; Hashimoto, Ichiro; Nakanishi, Hideki; Kurashiki, Taeko (2011). "Calcifying aponeurotic fibroma of the elbow: a case report". The Journal of Medical Investigation. 58 (1, 2). University of Tokushima Faculty of Medicine: 159–162. doi:10.2152/jmi.58.159. ISSN1343-1420. PMID21372502.
Further reading
Fetsch, John F; Miettinen, Markku (1998). "Calcifying aponeurotic fibroma: A clinicopathologic study of 22 cases arising in uncommon sites". Human Pathology. 29 (12). Elsevier BV: 1504–1510. doi:10.1016/s0046-8177(98)90022-3. ISSN0046-8177.