Location of AMC members: current, associate, departing
The conference began as the Show-Me Conference in 1986, then changed to its current name in 1994, reflecting that its footprint had expanded beyond Missouri.
2008 – Stephens College joined the American Midwest in the 2008–09 academic year.
2009 – Illinois–Springfield (UIS) left the American Midwest and the NAIA to join the NCAA Division II ranks and the Great Lakes Valley Conference (GLVC) after the 2008–09 academic year.
2009 – Park re-joined back to the American Midwest in the 2009–10 academic year.
2011 – McKendree left the American Midwest and the NAIA to join the NCAA Division II ranks as an NCAA D-II Independent (which would later join the GLVC beginning the 2012–13 academic year) after the 2010–11 academic year.
2020 – Three institutions left the American Midwest to join their respective new home primary conferences: Freed–Hardeman to join the Mid-South Conference, Lindenwood–Belleville to cease operations, and Park to join the Heart of America Athletic Conference (HAAC), all effective after the 2019–20 academic year.
2020 – Marian (Ind.) left the American Midwest as an associate member for men's wrestling after the 2019–20 academic year.
2020 – Lincoln College of Illinois joined the American Midwest as an associate member for men's wrestling in the 2020–21 academic year.
2022 – Lincoln (Ill.) left the American Midwest as an associate member for men's wrestling as the school announced that it would close after the 2021–22 academic year.
2023 – Lyon announced that it will leave the American Midwest and the NAIA to join the NCAA Division III ranks and the SLIAC after the 2022–23 academic year.[1] Currently Lyon competes in NCAA Division III as a provisional full independent for the 2022-23 academic year.
2023 – Haskell Indian Nations University joined the American Midwest as an associate member for men's & women's indoor & outdoor track & field in the 2024 spring season (2023–24 academic year).
^Represents the calendar year when fall sports competition begins.
^Represents the calendar year when spring sports competition ends.
^The Benedictine–Springfield men's and women's basketball teams joined the American Midwest a year after becoming a full member for other sports (2012–13).
^Currently known as Fontbonne University since 2002.